Naruto: Shippuden Isai (Season 1, Episode 452)
TV-14
TV Episode | 23 min | Animation, Action, Adventure

Naruto: Shippuden

Isai (Season 1, Episode 452)

TV-14

TV Episode | 23 min | Animation, Action, Adventure

Having experienced the Great Ninja War as a young child, Itachi constantly questions the meaning the life and death, distancing him from other children his age. Soon after entering the Academy, Itachi exhibits his genius and finds himself ...See moreHaving experienced the Great Ninja War as a young child, Itachi constantly questions the meaning the life and death, distancing him from other children his age. Soon after entering the Academy, Itachi exhibits his genius and finds himself at the top of his class. Written by TheTVDB See less

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Cast	+ Add Cast
24 cast members

Name	Known for
Yuka Terasaki Young Itachi Uchiha (voice) Young Itachi Uchiha (voice) See fewer	Your Name. (2016)
Nao Tôyama Sasuke Uchiha (Infant) (voice) Sasuke Uchiha (Infant) (voice) See fewer	Nisekoi (2014)
Kengo Kawanishi Young Shisui Uchiha (voice) Young Shisui Uchiha (voice) See fewer	Demon Slayer: Kimetsu no Yaiba Infinity Castle (2025)
Akiha Matsui Izumi (voice) Izumi (voice) See fewer	Alita: Battle Angel (2019)
Kenji Hamada Fugaku Uchiha (voice) Fugaku Uchiha (voice) See fewer	Transformers: Dark of the Moon (2011)
Emi Sagara Mikoto Uchiha (voice) Mikoto Uchiha (voice) See fewer	Tiger & Bunny the Movie: The Beginning (2012)
Hidekatsu Shibata Hiruzen Sarutobi, The Third Hokage (voice) Hiruzen Sarutobi, The Third Hokage (voice) See fewer	Fullmetal Alchemist the Movie: Conqueror of Shamballa (2005)
Hiroshi Ito Danzô (voice) Danzô (voice) See fewer	Castle in the Sky (1986)
Mariko Higashiuchi Kamano (voice) Kamano (voice) See fewer	Naruto: Shippuden (2007)
Ryûichi Kijima Daikoku (voice) Daikoku (voice) See fewer	Boruto: Naruto the Movie (2015)
Minoru Kawai Dokan (voice) Dokan (voice) See fewer	Final Fantasy XV (2016)
Kôsuke Gotô Academy Student (voice) Academy Student (voice) See fewer	Transformers: Robots in Disguise (2014)
Yô Tokinaga Academy Student (voice) Academy Student (voice) See fewer	NieR:Automata Ver1.1a (2023)
Mirei Kumagai Academy Student (voice) Academy Student (voice) See fewer	Sword Art Online (2012)
Sara Matsumoto Academy Student (voice) Academy Student (voice) See fewer	Boruto: Naruto Next Generations (2017)
Alexandre Crepet Iruka, Shino, Madara, Obito (voice) Iruka, Shino, Madara, Obito (voice) See fewer	Naruto: Shippuden (2007)
William Frederick Knight Danzo Shimura (voice: English version) (as Willam Knight) Danzo Shimura (voice: English version) (as Willam Knight) See fewer	Ghost in the Shell (1995)
Steve Kramer Hiruzen Sarutobi, The Third Hokage (voice: English version) Hiruzen Sarutobi, The Third Hokage (voice: English version) See fewer	The Day the Earth Stood Still (2008)
Erica Mendez Sasuke Uchiha (Infant) (voice: English version) Sasuke Uchiha (Infant) (voice: English version) See fewer	Aggretsuko (2018)
Cassandra Lee Morris Izumi (voice: English version) (as Cassandra Morris) Izumi (voice: English version) (as Cassandra Morris) See fewer	Your Name. (2016)
Nicolas Roye Young Shisui Uchiha (voice: English version) Young Shisui Uchiha (voice: English version) See fewer	Spidey and His Amazing Friends (2021)
Michelle Ruff Young Itachi Uchiha (voice: English version) Young Itachi Uchiha (voice: English version) See fewer	Akira (1988)
Doug Stone Fugaku Uchiha (voice: English version) Fugaku Uchiha (voice: English version) See fewer	Ninja Scroll (1993)
Kari Wahlgren Mikoto Uchiha (voice: English version) Mikoto Uchiha (voice: English version) See fewer	Rick and Morty (2013)