Name	Known for
Ellen Pompeo Dr. Meredith Grey Dr. Meredith Grey See fewer	Grey's Anatomy (2005)
Sandra Oh Dr. Cristina Yang Dr. Cristina Yang See fewer	Killing Eve (2018)
Katherine Heigl Dr. Izzie Stevens Dr. Izzie Stevens See fewer	One for the Money (2012)
Justin Chambers Dr. Alex Karev Dr. Alex Karev See fewer	Grey's Anatomy (2005)
T.R. Knight Dr. George O'Malley Dr. George O'Malley See fewer	The Flight Attendant (2020)
Chandra Wilson Dr. Miranda Bailey Dr. Miranda Bailey See fewer	Grey's Anatomy (2005)
James Pickens Jr. Dr. Richard Webber Dr. Richard Webber See fewer	Grey's Anatomy (2005)
Sara Ramirez Dr. Callie Torres Dr. Callie Torres See fewer	Grey's Anatomy (2005)
Eric Dane Dr. Mark Sloan Dr. Mark Sloan See fewer	X-Men: The Last Stand (2006)
Chyler Leigh Dr. Lexie Grey Dr. Lexie Grey See fewer	Not Another Teen Movie (2001)
Patrick Dempsey Dr. Derek Shepherd Dr. Derek Shepherd See fewer	Grey's Anatomy (2005)
Edward Herrmann Dr. Norman Shales Dr. Norman Shales See fewer	Overboard (1987)
Michael McGrady Stanley Singer Stanley Singer See fewer	Ray Donovan (2013)
Matt Lanter Adam Singer Adam Singer See fewer	Disaster Movie (2008)
Maggie Siff Ruthie Sales Ruthie Sales See fewer	Push (2009)
Miriam Flynn Gretchen Bitzer Gretchen Bitzer See fewer	Babe (1995)
Camille Winbush Camille Travis Camille Travis See fewer	The Bernie Mac Show (2001)
Ron Melendez Will Will See fewer	American Horror Story (2011)
Loretta Devine Adele Webber Adele Webber See fewer	Crash (I) (2004)
Shelley Robertson Arlene Arlene See fewer	Bel-Air (2022)
Jeremy Rabb ER Doctor ER Doctor See fewer	Silicon Valley (2014)
Maile Flanagan Lab Tech Lab Tech See fewer	Lab Rats (2012)
Tymberlee Hill Intern Claire (as Tymberlee Chanel) Intern Claire (as Tymberlee Chanel) See fewer	Due Date (2010)
Gloria Garayua Intern Graciella Intern Graciella See fewer	Maid (2021)
Richard Keith Intern Mitch Intern Mitch See fewer	Fall (VII)
Molly Kidder Intern Megan Intern Megan See fewer	Luckiest Girl Alive (2022)
Joy Osmanski Intern Lucy Intern Lucy See fewer	Stargirl (2020)
Mark Saul Intern Steve Intern Steve See fewer	Grey's Anatomy (2005)
Winston Story Intern Leo Intern Leo See fewer	Brooklyn Nine-Nine (2013)
Cassandra Braden Housekeeping Staffer Housekeeping Staffer See fewer	Alexander and the Terrible, Horrible, No Good, Very Bad Day (2014)
Nicole Rubio Paramedic Nicole (as Nicole Cummins-Rubio) Paramedic Nicole (as Nicole Cummins-Rubio) See fewer	Star Trek (2009)